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KMID : 0363620060270040096
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 4 p.96 ~ p.104
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Antihyperlipidemic and Antioxidant Effects of Insamsansa-eum (Renshenshanzha-yin) in Hypercholesterolemic Rats
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Kim Young-Suk
Kang Kyoung-Suk
Park Sung-Wook
Jung Woo-Sang
Moon Sang-Kwan
Park Jung-Mi
Ko Chang-Nam
Cho Ki-Ho
Bae Hyung-Sup
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Abstract
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Insamsansa-eum (Renshenshanzha-yin, ISE) is a new medicine developed to prevent and treat atherosclerotic diseases. To explore antiatherosclerotic effects of ISE, we evaluated the effects of ISE on serum lipids of hypercholesterolemic rats in vivo, as well as its antioxidant activities in vitro. In vitro, ISE showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide radical scavenging activities, and inhibited hemolysis induced by 2,2’’ -azobis-2-amidinopropane dihydrochloride (AAPH) in a dose-dependent manner. In vivo, ISE significantly inhibited increase of total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglyceride (TG) values in both high cholesterol diet and Triton WR-1339 models. It also significantly inhibited decrease of high-density lipoprotein cholesterol (HDL) value in the high cholesterol diet model. Collectively, our data suggest that ISE has the potential to control the risk of atherosclerosis development.
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KEYWORD
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Insamsansa-eum (Renshenshanzha-yin, ISE), antioxidant, hyperlipidemia, atherosclerosis
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